GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs4763555 | 1 | rs4763555 | chr12:10721456 | KLRA1 | chr12:10741078-10752434:- | 0.12 | 3.62 | 0.000328 | Cognitive function |
| THCA | cis | rs4763555 | 1 | rs4763555 | chr12:10721456 | MAGOHB | chr12:10756794-10766183:- | -0.16 | -3.74 | 0.000208 | Cognitive function |
| THCA | cis | rs4763879 | 1 | rs4763879 | chr12:9910164 | CLECL1 | chr12:9868457-9885860:- | -0.26 | -8.67 | 6.6E-17 | Type 1 diabetes |
| THCA | cis | rs4764124 | 1 | rs4764124 | chr12:14966604 | C12orf60 | chr12:14956506-14976789:+ | -0.41 | -10.26 | 1.94E-22 | Pubertal anthropometrics |
| THCA | cis | rs4764124 | 1 | rs4764124 | chr12:14966604 | ERP27 | chr12:15066977-15091463:- | -0.25 | -4.84 | 1.77E-6 | Pubertal anthropometrics |
| THCA | cis | rs4765219 | 1 | rs4765219 | chr12:124440110 | ZNF664 | chr12:124457670-124499967:+ | -0.18 | -5.15 | 3.78E-7 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs4765219 | 1 | rs4765305 | chr12:124430612 | DNAH10 | chr12:124247042-124420265:+ | 0.18 | 3.87 | 0.000126 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs4765219 | 1 | rs4765305 | chr12:124430612 | ZNF664 | chr12:124457670-124499967:+ | -0.16 | -4.81 | 1.98E-6 | Waist-to-hip ratio adjusted for body mass index |
| THCA | cis | rs476633 | 1 | rs476633 | chr15:41392134 | INO80 | chr15:41271081-41408340:- | 0.14 | 3.81 | 0.000159 | Glomerular filtration rate (creatinine) |
| THCA | cis | rs476633 | 1 | rs476633 | chr15:41392134 | RTF1 | chr15:41709302-41775760:+ | -0.18 | -4.23 | 2.83E-5 | Glomerular filtration rate (creatinine) |
| THCA | cis | rs4766428 | 1 | rs4766428 | chr12:110723245 | C12orf24 | chr12:110906229-110928191:+ | 0.18 | 3.9 | 0.000108 | Schizophrenia |
| THCA | cis | rs4766428 | 1 | rs4766428 | chr12:110723245 | VPS29 | chr12:110929331-110939916:- | -0.13 | -3.47 | 0.000567 | Schizophrenia |
| THCA | cis | rs4767841 | 1 | rs4766947 | chr12:120161401 | TMEM233 | chr12:120031264-120079363:+ | -0.21 | -5.12 | 4.47E-7 | Urgency urinary incontinence |
| THCA | cis | rs4767841 | 1 | rs4767839 | chr12:120160122 | TMEM233 | chr12:120031264-120079363:+ | -0.23 | -5.72 | 1.9E-8 | Urgency urinary incontinence |
| THCA | cis | rs4767841 | 1 | rs4767841 | chr12:120162199 | TMEM233 | chr12:120031264-120079363:+ | -0.22 | -5.42 | 9.61E-8 | Urgency urinary incontinence |